John Calvin Expelled
May 26 Geneva expels John Calvin and his followers from the city. Calvin lives in exile in Strasbourg for the next three years.
- Jun 10 Catholic German monarchy signs League of Neuremberg
- Jul 25 The City of Guayaquil is founded by the Spanish Conquistador Francisco de Orellana and given the name Muy Noble y Muy Leal Ciudad de Santiago de Guayaquil
- Aug 6 Bogotá, Colombia, is founded by Gonzalo Jiménez de Quesada
- Sep 21 Shrine of Saint Swithun in Winchester smashed up in the middle of the night as part of the English Reformation
- Sep 28 Battle at Preveza: Ottoman fleet under Barbarossa beats Papal alliance off Northwestern Greece
- Oct 28 The first university in the New World, the Universidad Santo Tomás de Aquino, is established on Hispaniola