- May 3 Ferdinand I officially appointed Holy Roman Emperor after his brother Charles abdicated in 1556
- Jul 13 Battle of Gravelines: In France, Spanish forces led by Count Lamoral of Egmont defeat the French forces of Marshal Paul des Thermes at Gravelines
- Jul 23 Battle of Grevelingen: Lamoraal, Count of Egmont beat France
- Aug 4 1st printing of Zohar (Jewish Kabbalah)
- Oct 9 Mérida is founded in Venezuela
Event of Interest
Nov 17 Elizabeth I aged 25, ascends the English throne upon death of her half sister, Queen "Bloody" Mary
- Nov 17 The independence of the Church of England is re-established upon ascension of Elizabeth I to the throne