Musicians Born in 1621
- Mar 7 Georg Neumark, German composer and poet, born in Langensalza (d. 1681)
- Mar 28 Heinrich Schwemmer, German composer, born in Gumpertshausen bei Hallburg, Lower Franconia (d. 1696)
Musicians Who Died in 1621
- Feb 15 Michael Praetorius [Schultze], German organist and composer (Syntagma; In Dulce Jubilo), dies at 49
- Jun 21 Kryštof Harant, Czech nobleman, soldier, writer, and composer, dies at about 57
- Oct 16 Jan Pieterszoon Sweelinck, organist/composer, dies at about 59
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