- Apr 3 157th Grand National: Graham Lee wins aboard Amberleigh House; trainer Ginger McCain's equal record 4th GN victory
- Apr 5 66th NCAA Men's Basketball Championship: Connecticut beats Georgia Tech, 82-73; Huskies' forward Emeka Okafor named tournament Most Outstanding Player
- Apr 6 23rd NCAA Women's Basketball Championship: Connecticut beats Tennessee, 70-61; UConn's Diana Taurasi is named Most Outstanding Player for the 2nd straight year
US Masters Golf
Apr 11 68th US Masters Tournament, Augusta National GC: Phil Mickelson claims his first major title with a birdie on the final hole to win by 1 stroke over Ernie Els of South Africa
Phil Mickelson
Ernie Els
Baseball Record
Apr 13 Barry Bonds hits his 661st career home run, passing his godfather Willie Mays on the MLB all-time list
Barry Bonds
- Apr 19 108th Boston Marathon: Kenyan double; Timothy Cherigat takes men's title in 2:10:37; Catherine Ndereba wins her 3rd women's event in 2:24:27
Event of Interest
Apr 24 NFL Draft: Ole Miss quarterback Eli Manning first pick by San Diego Chargers
Eli Manning